开发,优化和验证一种高度敏感和选择性的方法,用于动物性食品中PFAS的确定
Pascal Koenig1, Benedikt Brand1, Gerd Hamscher2
1Chemical and Veterinary Analytical Institute Westfalen, Westhoffstr. 17, 44791, Bochum, Germany.
Chemosphere
|January 25, 2025
概括
对于和多基基物质 (PFAS) 的敏感分析方法对于食品安全至关重要. 这项研究开发了一种双重SPE方法,在各种食品矩阵中检测四种EFSA-PFAS,揭示了物种依赖的积累和潜在的TWI超值.
科学领域:
- 环境化学环境化学
- 食品安全分析 食品安全分析
- 毒理学 毒理学 毒理学
背景情况:
- 和多基基物质 (PFAS) 是在食物网中积累的持久性环境污染物.
- 欧洲食品安全局 (EFSA) 在2020年为四个关键的PFAS确定了可容忍每周摄入量 (TWI).
- 敏感的分析方法对于监测PFAS水平和评估风险至关重要.
研究的目的:
- 开发和验证一种敏感的分析方法,用于在多种食物矩阵中量化四种EFSA-PFAS.
- 调查这些PFAS在不同动物来源食品中的积累情况.
- 评估潜在的饮食暴露相对于确定的TWI.
主要方法:
- 采用双固相提取 (SPE) 方法来净化样品.
- 液体染色学与双重质谱学 (LC-MS/MS) 结合使用用于检测.
- 分析方法验证包括对蛋,肝脏,牛奶和乳制品的量化限值 (LOQ) 的确定.
主要成果:
- 该方法实现了高灵敏度,LOQ范围从0.165 ng/kg (PFNA) 到46.0 ng/kg (PFHxS) 在矩阵中.
- 在牛肝 (396 ng/kg),猪肝 (54.0 ng/kg),奶酪 (8.46 ng/kg) 和牛奶 (4.57 ng/kg) 中检测到四种EFSA-PFAS的中位数度.
- 在牛肝和猪肝之间观察到PFAS水平的显著相关性,表明了特定物种的积累模式.
结论:
- 开发的双重SPE-LC-MS/MS方法提供了对食品中EFSA-PFAS的敏感和可靠量化.
- 根据动物物种和食物矩阵,PFAS的积累量有很大差异.
- 饮食暴露模型表明,儿童的潜在TWI疲劳超过27%,特别是来自肝脏,牛奶和奶酪的消费.
关键词:
动物性食品是以动物为基础的.液体染色学与双重质谱学 (LC-MS/MS) 结合使用-和多基基物质 (PFAS) 的使用.固相提取 (SPE) 是一种固相提取方法.可容忍的每周摄入量 (TWI)更多相关视频
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