双醇对成年人甲状腺功能的负面影响,双醇A暴露水平超过了可容忍的每日摄入量
Ziwei Pei1, Lei Zhang2, Yan Bao2
1NHC Key Laboratory of Public Nutrition and Health, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Ecotoxicology and environmental safety
|January 25, 2025
概括
在中国成年人中,双甲 (BPA) 暴露明显超过安全限值,可能会影响甲状腺功能,特别是在男性中. 双F (BPF) 与双性别的甲状腺抗体阳性有关.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 最近欧洲食品安全局 (EFSA) 的重新评估大大降低了双A (BPA) 的每日可容忍摄入量 (TDI).
- 关于双 (BPs),包括BPA和双F (BPF) 的健康影响,公众的担忧重新浮出水面.
- 甲状腺功能是一个关键的内分泌参数,可能对环境化学物质暴露敏感.
研究的目的:
- 评估中国一般成年人中各种双 (BPs) 的内部暴露水平.
- 为了研究尿路血压水平和甲状腺功能标志物之间的关系.
- 评估BP暴露与亚临床甲状腺功能低下症 (SCH) 和甲状腺抗体阳性之间的关联.
主要方法:
- 一项涉及1486名年龄在18-68岁之间的健康成年人的横截面研究,在中国成都.
- 在尿样中测量六个双 (BPs).
- 应用多变量回归模型和趋势测试来分析BP与甲状腺功能指标之间的关联.
主要成果:
- 双甲 (BPA) 是主要的尿动血压,估计每日摄入量 (EDI) 超过了新的TDI的两个数量级.
- 在男性中,较高的BPA含量与三甲氨酸 (T3) 和T3 / 甲氨酸 (T4) 比率有负面关联.
- 增加的BPA水平与男性亚临床甲状腺功能障碍症 (SCH) 的更高率相关 (OR=1.383).
- 双F (BPF) 暴露与男性和女性的甲状腺球蛋白抗体 (TGAb) 阳性有关.
结论:
- 中国成年人的尿液中BPA水平明显超过了既定的安全限值,这表明BPA暴露范围广泛.
- 双甲 (BPA) 暴露与甲状腺激素水平的改变以及男性亚临床甲状腺功能低下症 (SCH) 的风险增加有关.
- 双F (BPF) 暴露可能导致自身免疫性甲状腺疾病,如甲状腺球蛋白抗体 (TGAb) 阳性所示.
- 尽管有限制,但双 (BPs) 的不良健康影响需要继续关注公共卫生和进一步研究.
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