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Updated: May 30, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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双重向PPARα和NPC1L1代谢漏洞阻断了瘤的发生

Xiaona You1, Xi Hu2, Zenghui Sun2

  • 1Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China; School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.

Cancer letters
|January 25, 2025
PubMed
概括

针对乳腺癌中的脂质代谢,这项研究发现,抑制尼曼-皮克C1-like 1 (NPC1L1) 以及激活过氧酶增殖器激活受体α (PPARα) 诱导癌细胞死亡并抑制瘤生长.

关键词:
脂质新陈代谢 脂质新陈代谢NPC1L1L1 的使用情况在PKM2中,PKM2是PKM2.这是一种PPARα.有协同效应的效应.

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