在大鼠中,抑制基底侧杏仁到前皮层的途径可以提高风险决策冲击任务期间的风险承担
Ni Liu1, Yu-Fei Li1, Xiao-Tong Zhao1
1Beijing Key Laboratory of Learning and Cognition, College of Psychology, Capital Normal University, Beijing, PR China.
Physiology & behavior
|January 25, 2025
概括
老鼠避免风险选择与潜在的冲击,但抑制底侧桃体到前皮层 (BLA→PL) 途径增加风险行为. 这一途径是处理不利条件下的风险和回报的关键.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 决策研究 决策研究
背景情况:
- 关于在净损失条件下的决策存在有限的研究.
- 基底侧杏仁到前极皮层 (BLA→PL) 途径对于与风险相关的选择至关重要.
- 了解这些机制可以为精神疾病研究提供信息.
研究的目的:
- 在涉及潜在冲击 (厌恶性刺激) 的条件下,没有保证的奖励的情况下,研究大鼠的决策.
- 检查BLA→PL路径在这些净损失场景中的特定作用.
主要方法:
- 使用风险决策冲击任务 (RDST),老鼠在某些或具有潜在冲击的风险选项之间进行选择.
- 使用克洛扎N-氧化物 (CNO) 操纵了BLA→PL通路的活动,以观察杆选择的影响.
- 在不同的条件下测量响应延迟和杆偏好.
主要成果:
- 冲击的存在减少了对风险杆的偏好,即使有潜在的回报.
- 抑制BLA→PL路径显著增加了风险杆的选择.
- BLA→PL路径的抑制导致对奖励和损失的敏感性增加.
结论:
- BLA→PL路径在调节冒险行为方面发挥着至关重要的作用,尤其是在可能出现厌恶结果的情况下.
- 这种途径的抑制改变了面对潜在的惩罚时寻求奖励行为的处理.
- 这些发现提供了对与风险相关的精神疾病背后的神经机制的见解.
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