在整个生殖寿命和中年妇女的认知功能中,月经周期的特征
Diana C Soria-Contreras1, Siwen Wang1, Makiko Mitsunami1
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
American journal of obstetrics and gynecology
|January 25, 2025
概括
成年期的不规则月经周期和青春期的更短周期与中年期的学习和记忆力差异有关. 这些发现强调了月经周期特征对认知健康的重要性.
科学领域:
- 生殖健康 生殖健康
- 神经科学是一个神经科学.
- 流行病学 流行病学
背景情况:
- 月经周期的特征可能表明荷尔蒙暴露和心血管疾病风险因素,这两者都与认知健康有关.
- 关于月经周期特征与认知功能之间的关联,流行病学数据有限.
研究的目的:
- 研究三个生殖阶段的月经周期特征与中年认知功能之间的关联.
主要方法:
- 在19904名女护士的纵向队列研究 (护士健康研究II) 中.
- 月经周期的规律性和长度被追溯评估 (青春期) 和前性评估 (成年期).
- 使用Cogstate简要电池测量认知功能,评估精神运动速度/注意力和学习/工作记忆.
- 线性回归模型根据众多的人口,生活方式和健康因素进行调整.
主要成果:
- 成年期 (年龄29-46岁) 的不规则月经周期与较低的学习/工作记忆得分有关.
- 在青春晚期 (18-22岁) 中,更短的月经周期长度 (≤25天) 与晚年学习/工作记忆较差有关.
- 对于青春期早期 (14-17岁) 的周期规律或成年期的周期长度,没有发现显著的关联.
- 最初周期规律,但在成年后变得不规律的女性的学习/工作记忆减少.
结论:
- 青少年周期长度 (≤25天) 和成人周期不规则性与中年期的学习/工作记忆减弱有关.
- 这些发现表明月经周期模式可能作为认知健康轨迹的指标.
- 需要进一步的研究来证实这些关联在不同种群中,并探索潜在的生物机制.
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