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新型含有异醇烯的化合物,具有针对Mycobacterium tuberculosis的活性

Gabrielle Martinez1, Kirsten Tolentino1, Paridhi Sukheja1

  • 1Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, La Jolla, CA 92037, United States.

Bioorganic & medicinal chemistry letters
|January 25, 2025
PubMed
概括

研究人员确定了一种新型的异醇硫化合物,可以激活Mycobacterium tuberculosis (Mtb) 中的Rv1625c/Cya. 虽然模拟P15显示出有希望的巨细胞内活性和口服生物可用性,但有限的结构-活性关系阻止了进一步的发展.

关键词:
胆固醇 胆固醇 胆固醇细胞毒性 细胞毒性正式的打击概况.击中以领先的方式.结核病菌菌菌的结核病菌的结核病菌.药物动力学 药物动力学在Rv1625c/Cya中使用.结构活动关系结构活动关系

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