术后的血D-二聚物水平可能预测中风患者内血管治疗中无效的再通道化
Min Zhao1, Zhengze Dai2, Rui Liu3
1Department of Intensive Care Unit, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029 Jiangsu, China; Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002 Jiangsu, China.
概括
术后高的d-二分体水平和内血管治疗 (EVT) 后的显著增加可能预测急性缺血性中风患者的不良结果. 这一发现有助于评估再输血治疗的有效性.
科学领域:
- 神经学 神经学
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 升高的d-二聚物水平与急性缺血性中风的不良结果有关.
- 对于d-二分体对再注射治疗后的结果的影响,仍未得到充分的研究.
研究的目的:
- 为了研究血清d-二次体水平和在接受急性缺血性中风内血管治疗 (EVT) 的患者的功能结果之间的关联.
主要方法:
- 分析了接受成功EVT的急性缺血性中风患者.
- 在EVT前和之后测量了血d-二聚合物水平.
- 虚空的再通道被定义为90天后修改的兰金尺度3-6的得分.
- 多变量逻辑回归确定了d-二次体和徒劳的重通道化之间的关系.
主要成果:
- 术后高的d-二次体水平与徒劳的再化相关 (OR,1.25;P=0.016).
- 在无效再通道化 (P<0.001) 的患者中,在EVT后观察到d-二分体的显著增加.
- 在EVT后的d-二元变化独立地预测了徒劳的再通道化 (OR,1.33;P=0.005).
结论:
- 手术后的d-二次体水平及其在EVT后的增加可以预测急性缺血性中风中徒劳的再通道化.
- 这些发现凸显了d-二聚合物作为潜在的治疗中风患者治疗疗效的生物标志物.
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