羊奶蛋白水解剂中具有抗氧化和ACE抑制特性的生物活性:体学和分子对接研究
Wenhua Zhang1, Mohamed Aamer Abubaker1, Zekun Li1
1College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, Shaanxi, China.
International journal of biological macromolecules
|January 25, 2025
概括
羊奶具有强烈的抗氧化剂和血管酶转化酶 (ACE) 抑制作用. 这些生物活性为控制氧化应激和高血压提供了潜在的自然治疗益处.
科学领域:
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 羊奶蛋白是生物活性的潜在来源.
- 氧化应激和高血压是严重的健康问题.
- 酶性水解可以从蛋白质中释放生物活性.
研究的目的:
- 从山羊奶蛋白中识别和表征生物活性.
- 为了研究这些的抗氧化和 ACE 抑制活性.
- 阐明它们生物活性的分子机制.
主要方法:
- 羊奶蛋白的酶性水解.
- 用于的识别和测序的组学.
- 分子对接用于机制调查.
- 在体外测定抗氧化剂 (DPPH) 和 ACE 抑制活性.
主要成果:
- 确定了生物活性的特定氨基酸序列.
- 量化了ACE抑制 (IC50值:2.087-7.584毫克/毫升) 和抗氧化活性 (IC50值:3.875-4.626毫克/毫升).
- 已被确定的强有力的抗氧化和ACE抑制潜力.
结论:
- 羊奶是生物活性的宝贵来源.
- 这些对氧化应激和高血压具有显著的治疗潜力.
- 进一步的研究可以探索它们在功能性食品和药品中的应用.
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