碳支持的Fe单原子纳米酶具有持久的ROS生成和高NIR光热性能,用于协同的癌症治疗
Chengyang Fang1, Dandan Wang2, Xinyi Shi1
1High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Science, Hefei, Anhui 230031, PR China; University of Science and Technology of China, Hefei, Anhui 230026, PR China.
这项研究引入了一种新的基于铁的纳米酶,用于协同的癌症治疗. 它结合了光热疗法 (PTT) 和化学动力疗法 (CDT) 进行增强的瘤剥离和持续的氧化应激,显示出显著的瘤生长抑制.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 协同光热疗法 (PTT) 和化学动力疗法 (CDT) 在癌症治疗方面显示出有前途.
- 在PTT/CDT中常见的催化剂过早耗尽反应性氧物种 (ROS),降低治疗效率.
- 对于组合PTT/CDT,需要具有持续ROS生成的催化剂.
研究的目的:
- 开发一种基于碳的纳米酶,具有单个Fe原子 (Fe SAzyme),用于持续生成ROS.
- 评估Fe SAzyme在结合PTT和CDT治疗癌症方面的有效性.
- 为了应对在协同癌症治疗中催化剂耗尽的挑战.
主要方法:
- 一种含有单个Fe原子的碳基纳米酶 (Fe SAzyme) 的合成.
- 评估FeSAzyme的过氧化酶 (POD) 活性和光热转换效率 (64.78%在808nm).
- 在体外和体内研究评估瘤切除,持续的ROS生成和瘤生长抑制.
主要成果:
- SAzyme表现出强大的POD活性和高光热转换效率.
- 通过FeSAzyme的短期高温导致了瘤的快速切除.
- 持续的ROS生成由FeSAzyme诱导持续的氧化应激,显著抑制瘤生长在体外和体内.
结论:
- FeSAzyme有效地结合了PTT和CDT,用于增强癌症治疗.
- 纳米酶的持续ROS生成克服了催化剂耗尽的限制.
- FeSAzyme显示出作为有效癌症治疗的有力药物具有显著的潜力.
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