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在自身免疫性肝炎中,对阿扎西奥普林治疗的反应取决于谷氨转移酶基因型

Malin Lindqvist Appell1, Ulf Hindorf2, Sven Almer3

  • 1Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
|January 25, 2025
PubMed
概括

谷氨转移酶基因变异 (GSTM1和GSTT1 CNV) 影响了在自身免疫性肝炎 (AIH) 中阿扎西奥普林 (AZA) 治疗的有效性. 这些遗传因素影响肝酶水平,但不影响代谢物度,突出显示了AZA有效性中的非酶作用.

关键词:
这是GSTM1的标准.GSTT1,硫氨酸,药物遗传学谷氨转移酶 M1 的作用.谷氨转移酶 T1 的作用.

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