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基于液体的封装用于在广泛的pH环境中植入生物电子设备.
He Sun1, Xiaoting Xue2, Gabriella L Robilotto3,4
1Department of Biomedical Engineering and the Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.
Nature communications
|January 25, 2025
概括
一种新的基于液体的封装可以在极端pH环境中保护可植入的生物电子产品. 这种灵活,透明的材料确保了设备的功能和生物相容性,用于先进的医学研究和临床应用.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 植入式设备 植入式设备
背景情况:
- 可穿戴和可植入的生物电子产品需要强大的封装才能长期发挥作用.
- 现有的材料在极端pH环境下失败,限制了应用.
- 封装必须平衡屏障特性与灵活性和生物相容性.
研究的目的:
- 为生物电子学开发一种新的基于液体的封装.
- 为了使设备在广泛的pH值范围内 (酸性到性) 能够工作.
- 确保在体内应用的灵活性,透明度和生物相容性.
主要方法:
- 开发了一种基于液体的封装方法.
- 评估了材料的光学透明度,伸展性和机械耐用性.
- 封装的无线光电子设备在体外测试了pH值1.5-9.9的耐水性.
- 在小鼠身上评估了体内生物相容性和设备的长期运行.
主要成果:
- 基于液体的封装显示出高光学透明度,伸展性和耐用性.
- 在极端酸性 (pH 1.5,4.5) 和性 (pH 9) 条件下,在试验室中获得了出色的耐水性.
- 这种封装在体内被证明是生物相容的.
- 在自由移动的小鼠中,封装设备在3个月内保持了稳健的运行.
结论:
- 开发的基于液体的封装有效地保护生物电子设备在极端pH环境中.
- 这一战略为可植入生物电子在各种研究和临床环境中提供了一个有前途的解决方案.
- 该材料的特性支持扩展设备功能和生物相容性,用于长期植入.
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