客观和主观衰老与过早死亡率的共同关联
Minghao Kou1, Hao Ma1, Xuan Wang1
1Department of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
npj aging
|January 25, 2025
概括
结合多种衰老指标,如听力损失,牙损失,跌倒和主观衰老,显著增加了过早死亡的风险,特别是在年轻人和那些不健康的生活方式. 这凸显了综合风险评估的必要性.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 客观和主观的衰老指标已知,但它们对过早死亡率的综合影响尚不清楚.
- 现有的研究往往孤立地研究衰老指标,限制了对累积影响的洞察力.
研究的目的:
- 调查一个多领域的老龄化指标框架和过早死亡率之间的关联.
- 解决了解各种衰老标志物对死亡风险的累积影响的差距.
主要方法:
- 利用了来自369,741名参与者的英国生物库数据,最初没有心血管疾病 (CVD) 和癌症.
- 分析了四个指标 (听力损失,牙损失,跌倒,主观衰老) 与所有原因/特定原因过早死亡率之间的关联,使用Cox比例危险模型.
- 在健康和退休研究中重复发现.
主要成果:
- 累积计数的衰老指标与所有原因,心血管疾病,癌症和其他原因过早死亡的风险显著增加有关.
- 与没有这些指标的参与者相比,所有四个指标的参与者面临着81%更高的任何原因过早死亡风险.
- 较年轻的参与者,那些不健康的生活方式和社会经济地位较低的个人中风险增加尤为明显.
结论:
- 整合客观和主观的衰老指标,可以更全面地了解过早死亡风险.
- 这种多领域的框架可以完善风险评估,并为与衰老相关的疾病提供有针对性的干预措施.
- 这些发现强调了一种整体方法对健康老龄化和预防过早死亡的重要性.
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