帕纳克斯人参提取物对通过降低细胞死亡相关基因调节的西斯诱导的AKI的保护作用
Reza Alipanah-Moghadam1, Vahideh Aghamohammadi2, Sina Seifi1
1Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
Scientific reports
|January 25, 2025
概括
帕纳克斯人参根提取物可以保护大鼠免受西斯普拉丁诱导的损伤. 这项研究表明,人参治疗减少了损伤,并降低了关键损伤标志物的表达,提供了潜在的治疗方法.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
- 自然产品 自然产品
背景情况:
- 西斯是一种广泛使用的化疗剂,具有显著的毒性.
- 由西斯普拉丁诱导的急性损伤 (AKI) 构成了临床挑战.
- 探索天然化合物对抗药物诱导的器官损伤的保护作用至关重要.
研究的目的:
- 在大鼠模型中评估Panax人参根提取物对西斯普拉丁诱导的损伤的保护作用.
- 为了研究人参的脏保护作用的潜在分子机制.
主要方法:
- 维斯塔鼠被分为对照组,思普拉丁组和两组人参提取物 (100毫克/公斤和200毫克/公斤) 治疗组.
- 用于诱导AKI,西斯普拉丁被使用,随后用人参提取物治疗.
- 评估了功能 (肌素水平),组织病理学和关键分子标记物的表达 (p21,p27,p53,TIMP2,IGFBP7,NF-κB).
主要成果:
- 人参提取物显著降低了血清肌素水平,与西斯普拉丁组相比.
- 组织病理学检查显示,用人参提取物治疗的老鼠的脏组织损伤减少.
- 在人参治疗组中,p21,p27,p53,TIMP2,IGFBP7和NF-κB的表达显著下调,表明细胞死亡和炎症减少.
- 观察到剂量依赖的效果,200mg/kg提取物显示出更大的保护.
结论:
- 帕纳克斯人参根提取物在老鼠中表现出显著的脏保护作用,防止西斯普拉丁诱导的AKI.
- 保护机制涉及NF-κB信号通路和诱导细胞死亡的基因的下调.
- 人参提取物代表了一种有前途的治疗候选人,可以减轻西斯的毒性.
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