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基于纳米结构的"实验室内"打印电极的电化学适应传感器用于选择性检测万科米

Malek Bibani^1,2, Magdolna Casian¹, Bogdan Feier³

¹Department of Analytical Chemistry, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 4 Pasteur Street, 400349, Cluj-Napoca, Romania.

Mikrochimica acta

|January 25, 2025

概括

一个新的一次性口味传感器可以快速,无标签地检测万科米辛 (VAN) 水平. 这种电化学传感器使用金纳米结构和aptamers进行敏感和选择性的现场vancomycin监测.

科学领域:

电分析化学电分析化学
生物传感器技术技术
纳米材料是一种纳米材料.

背景情况:

范科米辛 (VAN) 是一种关键的抗生素,需要精确的治疗药物监测.
目前用于VAN检测的方法可能耗时,不适合现场分析.
开发快速,灵敏和便携式传感器对于有效的VAN管理至关重要.

研究的目的:

设计和开发一种新的无标签,灵活和一次性口味传感器,用于在现场检测菌素.
为了利用金纳米结构 (AuNSs) 和aptamers提高电化学传感性能.
在复杂的生物矩阵中验证传感器的性能.

主要方法:

在实验室打印的碳电极 (C-PE) 上制造一次性吸食传感器,其功能与花花形黄金纳米结构 (AuNSs) 相结合.
作为生物识别元素的科米辛特异性胺体和作为阻断剂的短链硫醇的固定.
电化学阻抗光谱 (EIS) 用于无标签的万科米辛检测.
使用扫描电子显微镜 (SEM) 和原子力显微镜 (AFM) 进行表征.

主要成果:

AuNSs增强了电化学特性和aptamer固定效率.
吸食传感器证明了在广泛的度范围内 (50-1000 nM) 检测到无标签的万科米辛.
低检测极限 (LOD) 达到1.721nM,对常见干扰物具有良好的选择性.
在分析人体血清和牛奶样本中万科米辛水平的成功应用.

结论:

成功开发了一种强大而敏感的无标签口味传感器,用于检测万科米辛.
一次性传感器提供了一个有前途的平台,用于快速的,在现场治疗药物监测万科米.
整合AuNS显著提高了传感器性能,为改进的诊断铺平了道路.

关键词:

抗生素耐药性抗生素耐药性花形的金纳米结构.这就是EISIS.电化学适应传感器金纳米结构的黄金纳米结构.范科米辛检测检测方法

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