在癌症治疗中,GITRL增强了CAR-T细胞的细胞毒性和持久性

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Updated: May 30, 2025

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

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Binghe Tan1, Chuntian Tu2, Hao Xiong2

  • 1Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai 200241, China; BRL Medicine, Inc., Shanghai 201109, China.

Molecular therapy : the journal of the American Society of Gene Therapy
|January 26, 2025
PubMed
概括

在仿真抗原受体 (CAR) -T细胞中过度表达GITR连接体,可以提高它们的抗瘤活性和固体瘤中的持久性. 这种增强有望改善CAR-T细胞免疫疗法对抗具有挑战性的固体瘤癌症.

关键词:
在CART-T中,我们可以使用CAR-T.在GITRL中,GITRL是指GITRL.Th9 在线观看中心存储器 T 中心存储器 T 中心存储器固体瘤免疫疗法固体瘤免疫疗法

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