这是第一个报告的新型Candida tropicalis双胞胎序列类型1515引起的候选血病病例
Chuan H Ding1, Shiamala D Navarathinam1, Hui-Min Neoh2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Journal of infection in developing countries
|January 26, 2025
概括
一例Candida tropicalis血流感染病例发生在一名患有严重COVID-19肺炎的患者身上. 这种酵母菌株对常见的抗真菌药物表现出耐药性,突显出需要新的治疗策略.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 坎迪达菌种越来越多地被认为是机会性病原体,特别是在医疗机构.
- 风险因素包括内置设备,免疫抑制 (皮质类固醇,化疗) 和广泛的抗生素.
- 热带是一种与高发病率,死亡率和耐药性相关的重要病原体.
研究的目的:
- 在患有严重COVID-19肺炎的患者中报告由Candida tropicalis引起的候选血病病例.
- 为了突出孤立的Candida tropicalis菌株的抗真菌耐药性概况.
- 为了描述Candida tropicalis分离的遗传类型.
主要方法:
- 一个43岁的男性患者的病例报告,患有严重的COVID-19肺炎.
- 治疗包括全身皮质类固醇和广泛的抗生素.
- 血液培养物发现了Candida tropicalis;进行了抗真菌敏感性测试.
主要成果:
- 患者出现了复发性发烧和Candida tropicalis血流感染 (candidemia).
- 这种分离物对可纳和伏利可纳具有很高的耐药性,但仍然对乙甘敏感.
- 尽管对乙类药物敏感,但患者无法接受这种治疗,不幸的是他去世了.
结论:
- 热带菌可以导致严重的,耐药性感染免疫功能低下的患者,包括COVID-19患者.
- 通过多位置序列类型识别,分离的菌株被确定为一种新型的双胞胎序列类型 (ST 1515).
- 这一案例凸显了治疗侵袭性角膜炎的挑战,治疗选择有限.
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