Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Protein Complex Assembly02:41

Protein Complex Assembly

10.5K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
10.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Genomic landscape of drug binding and pharmacogenetic variation across diverse populations using SNPdrug3D.

Nature communications·2026
Same author

Discovery of Pan-TEAD Inhibitors That Disrupt YAP-TEAD Interaction as a Potential Therapy for Gastric Cancers and Mutant KRAS and EGFR Lung Cancers.

ACS medicinal chemistry letters·2026
Same author

Enzyme-Modified DOPA-Containing Silk Fibroin Bioadhesives with Dynamic Cross-Linking Properties.

ACS applied materials & interfaces·2026
Same author

2D Hybrid Functional Materials for Biological Interfaces.

ACS nano·2026
Same author

Suckerin Colloids and Hydrogels With Low Immunogenicity as Resorbable and Hemostatic Tissue Adhesives for Wound Healing.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Living Organs as Micro-Factories: Material-Producing Organoids.

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology·2026
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
查看所有相关文章

相关实验视频

Updated: May 30, 2025

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.1K

基于的复杂体稳定通过-π相互作用用于细胞工程

Yue Sun1, Xi Wu1, Jianguo Li2,3

  • 1Center for Sustainable Materials (SusMat), School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore.

Journal of the American Chemical Society
|January 26, 2025
PubMed
概括
此摘要是机器生成的。

研究人员开发了用于细胞内输送的协同体. 阴离子-π 相互作用增强了共体的稳定性,并使可调节的载荷释放成为可能,这对基因编辑工具和疗法具有前景.

更多相关视频

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.6K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.6K

相关实验视频

Last Updated: May 30, 2025

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.1K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

10.6K
Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
07:11

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

2.6K

科学领域:

  • 生物材料科学
  • 分子生物学
  • 纳米技术

背景情况:

  • 复杂的凝聚涉及相反充电的大分子的液态分离.
  • 基于的协同生物正在成为大型生物分子的有效细胞内输送载体.
  • 了解体组装/拆卸对于优化货物交付和释放动力学至关重要.

研究的目的:

  • 设计和描述可调整复杂协体形成的.
  • 调查特定氨基酸残留和分子间相互作用在同体稳定性的作用.
  • 评估这些协同生物在细胞内传递各种宏分子的潜力.

主要方法:

  • 系统地将阴离子,阴离子和芳香残留物纳入序列.
  • 调节分子间相互作用,包括-π相互作用,以控制协.
  • 植入基于二硫化物的自焚侧链以提高稳定性和控制释放.
  • 在体外和细胞内测试蛋白质,mRNA和CRISPR/Cas9系统的输送.

主要成果:

  • 阿尔金因和芳香残留物之间的-π相互作用显著稳定了协物.
  • 在蛋白质丰富的细胞内环境中触发了体解体和货物释放.
  • 移植的同胞体表现出增强的稳定性和高效的多样化载荷,包括mRNA和CRISPR/Cas9.
  • 在具有挑战性的细胞类型,如巨细胞中,成功进行了分娩.

结论:

  • 基于的协同生物为细胞内输送提供了多功能平台.
  • -π相互作用是设计稳定和响应性的关键.
  • 这种方法扩大了协同体在生物医学和生物技术中的潜力,特别是在基因编辑应用中.