在口腔状细胞癌中分级系统和围神经侵入 - - 一种特定于疾病的生存分析
S-N Aquino1, L-L de Souza, D Alvarenga
1Department of Oral Diagnosis, Piracicaba Dental School University of Campinas, 901, Limeira Avenue Postcode: 13414-903. Piracicaba-SP, Brazil sibele.aquino@ufjf.br.
Medicina oral, patologia oral y cirugia bucal
|January 26, 2025
概括
周围神经侵入 (PNI) 和晚期临床阶段显著影响口腔状细胞癌 (OSCC) 的存活率. 早期检测和积极的治疗策略对于改善OSCC患者的治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 癌症研究 癌症研究
背景情况:
- 口腔状细胞癌 (OSCC) 是一种侵略性的恶性瘤.
- 预后受到临床因素,分级系统和围神经侵入 (PNI) 的影响.
- PNI与较差的结果有关,包括复发和转移.
研究的目的:
- 评估OSCC使用三个分级系统.
- 评估PNI和临床病理参数对患者存活时间的影响.
主要方法:
- 对81个OSCC初级样本的分析.
- 使用深度侵入性边缘的恶性病变分级,世卫组织分级和组织病理风险评估进行组织病理学评估.
- S-100免疫组织化学用于PNI检测;Kaplan-Meier和Cox比例危险模型用于生存分析.
主要成果:
- 晚期临床阶段和多焦点PNI与降低生存率显著相关 (p<0.001,HR=4.07;p=0.017,HR=4.20).
- 没有淋巴结参与改善了生存率 (p=0.002,HR=0.37).
- 较高的组织学风险得分和辅助疗法与结果有关.
结论:
- 在OSCC中,PNI是临床阶段和组织学等级的关键预后因素.
- 对PNI患者来说,需要采取积极的治疗策略.
- 对预后标志物的进一步研究可以完善OSCC管理.
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