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老化前后的多乳酸微塑料通过破坏微生物群-肠-大脑轴引起斑马鱼的神经毒性

Qiuhui Qian¹, Qian Pu¹, Lihang Li¹

¹National and Local Joint Engineering Laboratory of Municipal Sewage Resource Utilization Technology, School of Environmental Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China.

Journal of hazardous materials

|January 26, 2025

概括

可生物降解的聚乳酸 (PLA) 微塑料 (MPs) 和老化的PLA (APLA) MPs通过破坏肠-大脑轴,导致斑马鱼的神经毒性. 胆酸补充减轻了这些有害影响,为环境干预提供了洞察力.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

聚乳酸 (PLA) 是一种具有生物相容性的可生物降解塑料替代品.
在水生环境中,PLA可以降解为微塑料 (MP),这一过程会使材料衰老.
老年人民解放军 (APLA) 议员表现出改变的表面特性,可能会影响他们的环境影响.

研究的目的:

在斑马鱼中研究PLA和APLAMPs的神经毒性作用.
探索肠-大脑轴在PLA/APLA诱导的神经毒性的作用.
评估胆酸补充剂在减轻这些毒性影响方面的潜力.

主要方法:

斑马鱼幼虫和成年人接触到不同度的PLA和APLAMPs.
进行了行为测定,神经元发育评估和组织学分析.
分析了肠道微生物群组成和神经递质水平.
评估了胆酸补充剂对神经毒性的影响.

主要成果:

PLA和APLAMP诱导了剂量依赖的神经毒性,包括行为变化和神经元损失.
APLA MPs表现出比PLA更大的毒性,可能是由于吸收增加.
暴露导致肠壁变薄,小缩短,肠道失调,并抑制了神经递质水平.
胆酸补充剂显著降低了PLA/APLA诱导的神经毒性.

结论:

通过肠-大脑轴,PLA和APLAMP对水生生物构成神经毒性风险.
肠-大脑轴是PLA/APLA MP毒性的关键途径.
胆酸补充剂在减轻可生物降解的MPs的不良影响方面显示出前景.
这些发现支持有针对性的干预措施,以减少可生物降解塑料对生态的影响.

关键词:

衰老的衰老衰老的衰老肠-大脑轴肠-大脑轴神经毒性神经毒性聚乳酸微塑料聚乳酸微塑料斑马鱼是一种斑马鱼.

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