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吸烟对口腔粘膜的影响:细胞学和细胞增殖研究

Magdi M Salih¹, Thamer A Tamr², Abdulhakeem S Alamri³

¹Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, King Fahad Road, Western Region, Taif 21974, Saudi Arabia.

|January 26, 2025

概括

吸烟显著增加了口腔细胞的增殖,并导致反应性变化,可通过AgNORs和Pap染色检测,甚至在症状出现之前. 这突出了吸烟的风险.

科学领域:

口腔病理学口腔病理学
细胞生物学细胞生物学
与烟草有关的疾病.

背景情况:

吸烟与口腔粘膜细胞变化和增殖有关.
了解这些影响对于早期发现和预防至关重要.

研究的目的:

为了比较吸烟者与非吸烟者的细胞增殖和细胞学变化.
评估AgNORs和Pap染色在检测吸烟引起的口腔变化的有效性.

主要方法:

对吸烟者和非吸烟者的平均AgNOR计数进行统计分析.
使用Pap染色对吸烟者的反应性细胞变化的评估.
在不同组之间记录和比较细胞学变化,包括炎症变化.

主要成果:

吸烟者表现出更高的平均AgNORs数量 (3.68),表明明显的反应性细胞变化.
炎症和反应性细胞变化在吸烟者中明显更为普遍 (分别为33.3%和59.3%).
吸烟会诱导上皮细胞的改变,并增加口腔粘膜细胞的增殖,即使没有临床症状.

结论:

吸烟会增加细胞的增殖,由增加的AgNORs数量证明.
帕普染色和AgNORs计数有效地检测到吸烟者的前症状细胞增殖.
建议对影响因素和比较扩散指标进行进一步的研究.

关键词:

阿格诺尔 (AgNOR) 是一个吸烟吸烟吸烟吸烟吸烟帕帕尼科拉是你的染色.

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