长期暴露于聚烯微塑料的环境会增加非酒精性脂肪肝疾病的风险
Yujie Shi1, Runyang Hong1, Zhencheng Fan1
1Yangzhou University Medical College, Yangzhou University, Yangzhou, Jiangsu Province 225009, China.
Toxicology
|January 26, 2025
概括
长期暴露于微塑料 (MPs) 在小鼠中引起非酒精性脂肪肝疾病 (NAFLD). 有正电荷的MP显示出更强的效应,通过HO-1/Nrf2通路诱导肝细胞衰老和铁亡.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 微塑料 (MP) 是普遍存在的环境污染物,具有潜在的人类健康影响.
- 微塑料暴露对长期影响的研究有限,特别是对肝脏健康的影响.
- 聚钢 (PS) 微塑料,包括未经修改和正电荷的变体,是常见的,需要调查.
研究的目的:
- 研究聚烯微塑料对小鼠肝脏健康的慢性体内影响.
- 阐明微塑料诱导的肝损伤背后的体外机制.
- 探索细胞衰老和铁死在微塑料诱导的非酒精性脂肪性肝病 (NAFLD) 中的作用.
主要方法:
- 小鼠被口服暴露于未经修改的PS MPs和正电荷的PS-NH2 MPs (10 mg/L) 六个月.
- 人类肝细胞细胞在体外用MPs (25μg/mL) 进行治疗,以研究细胞机制.
- 分析包括肝功能测试,脂质沉积评估,基因表达概况以及衰老和铁亡标志物的评估.
主要成果:
- 六个月的MP暴露诱导了NAFLD,其特点是肝功能受损和广泛的脂质积累.
- 带正电荷的PS-NH2 MPs表现出比未经修改的PS MPs更明显的效果.
- 暴露于MP导致肝细胞衰老和铁,由HO-1/Nrf2通路介导,由铁沉积和脂质过氧化证明.
结论:
- 长期暴露于微塑料与非酒精性脂肪肝疾病的发展有关.
- HO-1/Nrf2通路在调解微塑料诱导的铁亡和随后的细胞衰老方面发挥着关键作用.
- 针对HO-1/Nrf2通路提供了一种潜在的治疗策略,以减轻微塑料诱导的肝损伤.
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