不规律的早餐和深夜的零食与代谢功能障碍相关的脂肪性肝病的联系
Wenzai Shi1, Xiaopeng Suo2, Yiming Wang3
1Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China; Beijing Key Surgical Basic Research Laboratory of Liver Cirrhosis and Liver Cancer, Peking University People's Hospital, Beijing, China; Department of Hepatobiliary Surgery, Peking University International Hospital, Beijing, China.
Clinical nutrition (Edinburgh, Scotland)
|January 26, 2025
概括
不规律的早餐习惯和深夜的零食显著增加了患有代谢功能障碍相关脂肪性肝病 (MASLD) 的风险. 这些饮食模式破坏了代谢平衡,突出了肝脏健康的关键联系.
科学领域:
- 代谢健康和肝病研究研究.
- 营养流行病学 营养流行病学
- 公共卫生和生活方式干预措施
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越被认可,代谢风险因素发挥着关键作用.
- 饮食习惯,如不规律的早餐消费和深夜的零食,与能量平衡中断有关.
- 这些饮食模式与MASLD风险之间的特定关联以前没有被研究过.
研究的目的:
- 调查早餐和深夜零食消费模式与患MASLD的风险之间的关系.
- 探索与MASLD和酒精摄入量 (MetALD) 的关联.
主要方法:
- 从前性队列研究利用Kailuan队列的数据.
- 参与者填写了关于早餐和深夜零食频率的问卷.
- 考克斯回归和中介分析被用来评估MASLD/MetALD风险和BMI的中介作用.
主要成果:
- 总共有32,030名参与者被分析.
- 不规则的早餐和深夜的零食都独立地与增加MASLD风险有关.
- 特定的模式,包括从不吃早餐和深夜零食,显示最高的风险增加 (HR=1.52).
结论:
- 不定期或跳过的早餐和深夜的零食是MASLD的重要风险因素.
- 这些饮食行为也与MetALD的风险增加有关.
- 这些发现强调了定期的饮食时间对肝脏健康的重要性.
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