相关实验视频
Updated: May 30, 2025

07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
48.1K
在神经病痛中肠道微生物组和血清代谢物:PPARα视角
Yu-Ying Zhao1, Zi-Jun Wu1, Yue Du1
1Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin 300052, China.
Behavioural brain research
|January 26, 2025
概括
过氧体增殖器激活受体α (PPARα) 通过改变肠道微生物和代谢物来影响神经病痛. 向PPARα可能为这种慢性炎症状况提供新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经病痛 (NP) 是一种由神经炎症驱动的衰弱性慢性疾病.
- 目前对NP的治疗方法有限,通常是无效的.
- 肠道微生物组及其代谢物越来越多地被认为是它们在NP中的作用.
研究的目的:
- 为了调查是否Peroxisome增殖器激活受体α (PPARα) 影响神经病痛的发展和缓解.
- 确定PPARα是否影响NP中的肠道微生物群落和血清代谢物.
- 探索针对PPARα和NP的肠道微生物组的潜在治疗策略.
主要方法:
- 建立了一个慢性收缩损伤 (CCI) 鼠标模型用于神经病痛.
- 使用16S rDNA测序分析了肠道微生物组成.
- 在血清上使用LC-MS/MS进行非向代谢.
- 使用PPARα激动剂 (GW7647) 和抗剂 (GW6471) 来评估对疼痛和炎症的影响.
主要成果:
- CCI小鼠在肠道微生物群和血清代谢物中表现出显著的变化.
- PPARα激动剂GW7647减少了CCI小鼠的疼痛行为和微质激活.
- PPARα对手GW6471加剧了疼痛行为.
- 激动剂和对抗剂治疗都调节了肠道微生物的组成.
- 确定了258种与肠道微生物变化相关的血清代谢生物标志物.
结论:
- PPARα通过影响肠道微生物群组成和血清代谢物概况来调节神经病痛.
- 针对PPARα提供了一个有前途的治疗策略,用于神经病痛.
- PPARα,肠道微生物组和代谢物之间的相互作用在NP病变发生过程中至关重要.
相关概念视频
Analgesia and Pain Management
463
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
463
Nociception
27.7K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
27.7K
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Pain
443
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
443

