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Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
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新型三级二甲基乙胺作为卡帕阿片类受体的功能选择性激动剂

Thomas O Schrader1, Kym I Lorrain1, Matthew R Nelli1

  • 1Contineum Therapeutics, 3565 General Atomics Court, Suite 200, San Diego, CA 92121, United States.

Bioorganic & medicinal chemistry letters
|January 26, 2025
PubMed
概括

新型卡帕阿片类受体 (KOR) 激动剂被开发用于选择性地激活G蛋白信号,避免β-arrestin-2. 化合物39作为中枢神经系统疾病的潜在治疗药物具有前景,提供更好的安全性和耐受性.

关键词:
有偏差的激动剂激活剂.具有功能选择性的功能选择性.在GPCR中,GPCR是指GPCR.韩国 韩国 韩国卡帕的阿片类受体受体.多发性硬化症是多发性硬化症.雷米林的产生

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