描述营养和饮食相关的随机对照试验的情景:在2012年至2022年之间发表的协议的超级研究研究
Flávia Moraes Silva1, Amanda Rodrigues Amorim Adegboye2, Celeste Naude3
1Nutrition Department and Graduate Program of Nutrition Science, Federal University of Health Science of Porto Alegre, Porto Alegre, Brazil.
The American journal of clinical nutrition
|January 26, 2025
概括
发表的营养和饮食随机对照试验 (RCT) 协议的数量正在增加,突出显示了它们的重要性. 然而,期刊和研究人员遵守SPIRIT和CONSORT等报告准则需要改进,以提高透明度.
科学领域:
- 营养科学 营养科学
- 饮食干预 饮食干预
- 临床试验方法论 临床试验方法论
背景情况:
- 发表研究协议可以提高科学研究的透明度和可重复性.
- 营养和与饮食相关的随机对照试验 (RCT) 协议的风景,包括其范围和方法,尚未全面研究.
研究的目的:
- 绘制与营养和饮食相关的已发布RCT协议的特征和趋势.
- 评估在这个研究领域采用报告准则和透明度实践的情况.
主要方法:
- 一项分析了2012年1月至2022年3月期间发表的1068个营养和饮食相关的RCT协议的超级研究研究.
- 在6个数据库中进行系统的文献搜索,收集文献计量数据,研究特征和透明度实践.
- 审查关于报告准则的作者期刊指导方针,并在协议中提及这些准则.
主要成果:
- 观察到公布的协议每年显著增加 (平均103/年).
- 大多数协议报告了RCT注册 (94.2%),利益冲突 (89.1%) 和资金 (93.2%).
- 常见的干预措施包括补充剂 (37.9%) 和营养教育 (33.1%),临床状态是常见的初级结局 (28.8%).
- 虽然许多期刊认可CONSORT (75.3%),但更少的期刊认可SPIRIT (33.8%). 他们还注意到Spirit (32.1%) 和CONSORT (27.8%) 的协议提及.
结论:
- 越来越多的营养和饮食RCT协议出版反映了越来越多的认识和重要性.
- 期刊和研究人员广泛采用和提及关键报告准则 (SPIRIT,CONSORT,TIDieR) 仍然不够理想,这表明需要改进.
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