在多次比较中进行调整或不进行调整
1Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Journal of clinical epidemiology
|January 26, 2025
概括
解释多重假设测试需要仔细考虑调整. 虽然有些人反对纠正,但监管要求,特别是在药物试验中,通常需要它们来控制错误率.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 临床试验 临床试验
背景情况:
- 多重假设测试在解释结果方面存在挑战.
- 流行病学文献经常反对多重性调整.
- 监管要求,特别是在药物试验中,可能会要求进行调整.
研究的目的:
- 探索多重假设测试的调整解释的复杂性.
- 审查支持和反对多重性调整的论点.
- 为科学研究中的这些问题提供导航指南.
主要方法:
- 关于测试假设中的多重性的现有文献的综述.
- 讨论频率主义者对错误率控制的方法.
- 在流行病学和监管背景下对比观点的分析.
主要成果:
- 有关多重性调整的必要性和方法存在重大辩论.
- 监管机构通常需要进行调整,从而影响试验解释.
- 调整的正式依据经常与频率错误率控制有关.
结论:
- 没有关于多重性调整的普遍共识.
- 统计严谨性与监管合规性之间的平衡至关重要.
- 建议进一步阅读以获得全面的理解.
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