Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.1K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.1K
Collagens are the Major Structural Proteins of ECM01:13

Collagens are the Major Structural Proteins of ECM

4.0K
Three main types of fibers are secreted by fibroblasts: collagen fibers, elastic fibers, and reticular fibers. Collagen fiber is made from fibrous protein subunits linked together to form a long, straight fiber. Collagen fibers, while flexible, have great tensile strength, resist stretching, and give ligaments and tendons their characteristic resilience and strength. These fibers hold connective tissues together, even during the body's movement.
Connective tissue proper includes loose...
4.0K
The Bone Matrix01:18

The Bone Matrix

2.9K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
2.9K
Extracellular Matrix01:26

Extracellular Matrix

2.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Identification of TXNIP, FTCD, and HAGH as Key Genes in a Cancer Stem Cell-Driven Prognostic Model for Hepatocellular Carcinoma.

Endocrine, metabolic & immune disorders drug targets·2026
Same author

Effective recycling of spent lithium-ion batteries via radiolytic radical reactions.

Nature communications·2026
Same author

Reconfigurable silicon photonic transceiver for WDM BPSK non-coherent detection.

Optics express·2026
Same author

Molecular detection of Clostridium and Bacillus species in foods: recent advances and applications.

Food research international (Ottawa, Ont.)·2026
Same author

Psychometric Properties of the Chinese Version of the Anhedonia Scale for Adolescents and Identification of the Subpopulation with Prominent Anhedonia.

Neuropsychiatric disease and treatment·2025
Same author

All-fiber spatiotemporal self-similar laser.

Optics letters·2025

相关实验视频

Updated: May 30, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K

通过原介导的心血管化.

Junlin Chen1, Chunyang Ma1, Jinyu Li2

  • 1Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

International journal of biological macromolecules
|January 26, 2025
PubMed
概括
此摘要是机器生成的。

心血管化包括原蛋白作为支架和信号通路. 了解原蛋白的理解

关键词:
动脉样硬化是一种动脉样硬化.动脉的疾病 动脉疾病化是一种化过程.原蛋白是一种原蛋白.

更多相关视频

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.6K

相关实验视频

Last Updated: May 30, 2025

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

19.5K
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

1.9K
Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models
09:01

Analysis of Extracellular Vesicle-Mediated Vascular Calcification Using In Vitro and In Vivo Models

Published on: January 27, 2023

1.6K

科学领域:

  • 心血管生物学 心血管生物学
  • 生物化学 生化学
  • 病理学 病理学 病理学

背景情况:

  • 心血管化,包括血管和膜类型,在老年人中很普遍.
  • 原蛋白对心血管化至关重要,影响矿物沉积和细胞过程.
  • 原蛋白合成和降解之间的平衡至关重要;失调有助于病理结果.

研究的目的:

  • 在生理和病理条件下,审查心血管系统中的原蛋白亚型.
  • 阐明原蛋白在心血管化的形成和进展中的作用.
  • 探索调节心血管化中的原蛋白的策略.

主要方法:

  • 对原蛋白在心血管化中的作用的文献综述.
  • 对原蛋白亚型,分布和病理变化的分析.
  • 描述心血管化过程和阶段.

主要成果:

  • 原蛋白作为矿物沉积的支架,并通过信号传导调解化.
  • 它指导矩阵囊泡聚合,并影响化病变中的细胞行为.
  • 原蛋白的病理变化是心血管化的发展不可或缺的一部分.

结论:

  • 原蛋白是心血管化的关键媒介,影响结构和细胞信号传递.
  • 向原路径为心血管化提供了潜在的治疗策略.
  • 为了开发有效的干预措施,需要对原蛋白的动态作用进行进一步的研究.