相关实验视频

Updated: May 7, 2026

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

A Detailed Protocol for Physiological Parameters Acquisition and Analysis in Neurosurgical Critical Patients

Published on: October 17, 2017

在外科手术初始内压力证明了在经过严重创伤性脑损伤后的术后肠粘膜屏障功能障碍的高诊断效率

Chunlong Ding¹, Shaodong Xi², Li Xiao³

¹Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China; Department of Neurosurgery, Wuxi Branch of Zhongda Hospital Southeast University, Wuxi, Jiangsu, China.

World neurosurgery

|January 26, 2025

概括

在严重创伤性脑损伤 (sTBI) 患者中,术后初始内压力 (iICP) 的升高是术后肠粘膜屏障功能障碍 (IBD) 的重要危险因素. 这一发现为识别有风险的个体提供了有价值的预测指标.

科学领域:

神经科学是一个神经科学.
胃肠病学胃肠病学
临界护理医学临界护理医学

背景情况:

严重的创伤性脑损伤 (sTBI) 可以导致术后肠粘膜屏障功能障碍 (IBD).
在sTBI患者中确定IBD的风险因素对于改善患者的治疗结果至关重要.
目前对STBI后IBD预测因子的理解需要进一步调查.

研究的目的:

调查严重创伤性脑损伤 (sTBI) 患者中与术后肠粘膜屏障功能障碍 (IBD) 相关的风险因素.
评估已识别的风险因素对预测IBD在这个患者群体的诊断疗效.
确定术后IBD的临床变量的独立预测值.

主要方法:

分析了140名患有STBI的患者队列.
使用单变量和多变量逻辑回归来确定术后IBD的独立风险因素.
用接收器操作特征 (ROC) 曲线分析来评估风险因素的诊断效果.

主要成果:

该研究确定了60名IBD患者和80名没有IBD的患者.
较高的手术后初始内压力 (iICP) 与手术后IBD显著相关 (P < 0.001).
术内iICP显示IBD的高诊断效率 (AUC = 0.91),预测不良的神经结果.

结论:

术内iICP是STBI患者术后IBD的独立预测因子.
由于iICP的可量化性质和高诊断效率,使其成为评估风险的宝贵工具.
监测iICP可能有助于在sTBI患者中早期识别和管理IBD.

关键词:

肠道粘膜屏障的功能肠道粘膜屏障功能内压力内压力在ROC分析中,ROC分析风险因素风险因素创伤性脑损伤是一种创伤性脑损伤.

更多相关视频

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

A Bedside, Single Burr Hole Approach to Multimodality Monitoring in Severe Brain Injury

Published on: March 26, 2019

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Published on: September 19, 2019

相关概念视频

Traumatic Brain Injury l: Introduction

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

Increased Intracranial Pressure l: Introduction

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...

Increased Intracranial Pressure ll: Pathophysiology

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...