炎症参数和抗体血清转换对中枢肥胖症患者COVID-19结果的作用
Syahidatul Wafa1, Dicky Levenus Tahapary, Evy Yunihastuti
11. Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia. 2. Metabolic Disorder, Cardiovascular and Aging Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.. dokter.wafa@gmail.com.
Acta medica Indonesiana
|January 26, 2025
概括
在COVID-19患者中,中心肥胖与更糟糕的结果有关. 较高的炎症和较低的SARS-CoV-2抗体水平与较差的临床结果有关,这表明需要进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 中部肥胖是严重的COVID-19的已知风险因素之一.
- 将中心肥胖与COVID-19不良结果 (如炎症和抗体功能障碍) 联系在一起的机制需要进一步澄清.
研究的目的:
- 调查中心肥胖,炎症标志物,SARS-CoV-2抗体标位和住院COVID-19患者的临床结果之间的关联.
主要方法:
- 针对中部肥胖症的成年COVID-19住院患者进行了一项队列研究.
- 分析了临床数据,人类学,炎症性细胞因子和SARS-CoV-2 IgG S-RBD抗体标位.
- 使用后勤回归来确定糟糕结果的调整相对风险.
主要成果:
- 12.9%的患者经历了不良的临床结果.
- 糟糕的结果与较高的内脏脂肪面积,腰围,BMI和高水平的促炎和抗炎细胞因子有关.
- 较低的SARS-CoV-2抗体标位和抗体血清转化失败在不良结果的患者中观察到,增加了风险 (aRR 2.696).
结论:
- 在COVID-19患者中,中心肥胖与炎症增加和抗体反应减少有关.
- 这些免疫学变化与中央肥胖症COVID-19患者的临床结果较差相关.
相关概念视频
Obesity
371
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
371
Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25


