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Updated: May 30, 2025

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
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Published on: July 3, 2020

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骨祖先LRP1缺乏导致严重和持久的骨缺陷与Wnt通路调节失调

Mohammad Alhashmi1,2,3, Abdulrahman M E Gremida1, Santosh K Maharana4

  • 1Institute of Life Course and Medical Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK.

Bone research
|January 26, 2025
PubMed
概括

低密度脂蛋白受体相关蛋白1 (LRP1) 对于骨发育至关重要. 干细胞中的LRP1缺陷通过破坏Wnt/平面细胞极性信号,影响骨和关节形成,导致严重的骨缺陷.

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