心血管疾病减弱了叶酸对老年人总体认知功能的保护作用:一个横截面研究
Jianqiang Zhang1,2, Di Yue3, Huifeng Zhang4
1Department of Neurology, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Scientific reports
|January 26, 2025
概括
较高的红细胞叶酸水平与老年人认知障碍的几率较低有关. 然而,这种保护作用在患有心血管疾病的人群中减弱,这表明了复杂的相互作用.
科学领域:
- 老年学和营养神经科学
- 研究B族维生素对衰老和认知健康的影响.
背景情况:
- 叶酸因其在认知功能中的作用而得到认可,但对老年认知障碍者饮食和血液叶酸水平的全面研究是有限的.
- 心血管疾病 (CVD) 与认知能力下降有关,因此需要检查叶酸在心血管疾病和非心血管疾病老年人群中的作用.
研究的目的:
- 系统地调查饮食,血清和红细胞 (RBC) 叶酸水平与老年人的全球认知障碍 (CoI) 之间的关联.
- 探索心血管疾病 (CVD) 对叶酸状况和认知功能之间的关系的潜在影响改变.
主要方法:
- 分析了2011-2014年国家健康和营养检查调查 (NHANES) 的2104名参与者 (≥60岁) 的数据.
- 用验证的问卷和认知测试评估饮食和血液叶酸水平 (血清和红血细胞) 和全球认知功能.
- 应用多变量逻辑回归和受限立方线 (RCS) 来确定关联和非线性关系,包括与心血管疾病的相互作用分析.
主要成果:
- 红血细胞 (红血细胞) 叶酸水平与认知障碍 (CoI) 有显著的反向关联 (OR 0.86,95% CI 0.75-0.97).
- 较高的饮食叶酸总量,叶酸和红血细胞叶酸三位数与显著较低的冠状动脉炎的几率有关.
- 限制性立方脊柱分析显示,红血球叶酸和CIO之间存在线性负相关性,但心血管疾病 (CVD) 减弱了这种保护作用.
结论:
- 红血细胞 (RBC) 叶酸水平与美国老年人认知障碍 (CoI) 的风险较低显著相关.
- 红细胞叶酸对COI的保护性关联在患有心血管疾病 (CVD) 的个体中减弱,突出了关键的相互作用.
- 需要进一步的研究来阐明红细胞叶酸,心血管疾病和老年人认知健康之间的相互作用背后的机制.
相关概念视频
Cognitive Development During Adulthood
48
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
48
Vitamins
547
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
547
Alzheimer's Disease: Overview
439
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
439
Psychoneuroimmunology: Cardiovascular Disease
25
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
25
Alzheimer's Disease: Treatment
160
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
160
The Effect of Aging on Tissues
2.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.0K


