深海衍生真菌Trichoderma simmonsii ZEN3的化学组成部分
Yun-Fei Song1, Yuan Wang2, Zheng-Biao Zou2,3
1Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, China.
Chemistry & biodiversity
|January 26, 2025
概括
研究人员从深海真菌Trichoderma simmonsii中分离出了新的化合物. 一种化合物纳富瑞丁 (nafuredin) 强烈抑制了细胞死亡过程铁亡,这表明了潜在的治疗应用.
科学领域:
- 海洋天然产品化学 海洋天然产品化学
- 的二次代谢产物 的二次代谢产物
- 生物技术是生物技术.
背景情况:
- 深海微生物是新型生物活性化合物的丰富来源.
- 三体物种是众所周知的各种二次代谢物的生产者.
- 铁亡是治疗干预的新兴目标.
研究的目的:
- 从深海真菌Trichoderma simmonsii ZEN3.3中分离和描述新的化学实体.
- 评估分离化合物的生物活性,特别是它们对铁亡的作用.
主要方法:
- 使用色谱技术分离和净化化合物.
- 通过综合光谱分析 (NMR,HRESIMS) 和光旋分散 (ORD) 阐明结构.
- 在实验室中使用RSL3诱导的ferroptosis模型对抗ferroptosis活性进行评估.
主要成果:
- 确定了两种新的nor-rubrofusarin衍生物 (trichsimin A和B) 和一种新的染色体衍生物 (trichsimin C).
- 20种已知的化合物也被分离和表征.
- 纳富瑞丁显示出强烈的RSL3诱导铁亡的抑制,EC50值为5.54μM.
结论:
- 来自深海的Trichoderma simmonsii ZEN3产生结构独特的二次代谢产物.
- 纳富瑞丁表现出显著的抗铁灭活性,突出其作为治疗性化合物的潜力.
- 需要进一步研究nafuredin的作用机制和治疗潜力.
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