相关实验视频
Updated: Jun 20, 2026

05:12
Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
Published on: May 12, 2023
甲状腺切除术后胺-2-受体对抗剂对低热血的作用:回顾性队列研究和敏感性分析
Maxwell Rossip1, F Jeffrey Lorenz1, Bao Sciscent1
1Department of Otolaryngology-Head and Neck Surgery, Penn State College of Medicine, Hershey, Pennsylvania, USA.
概括
服用组胺-2-受体对抗剂 (H2RAs) 的患者在甲状腺手术后面临较高的低血症风险. 这项研究强调了甲状腺切除术后H2RA使用者短期和长期低血症风险的增加.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲状腺切除术是一种常见的外科手术.
- 低血是甲状腺切除术后的一个已知的并发症.
- 组胺-2受体对抗剂 (H2RAs) 是经常使用的药物.
研究的目的:
- 调查H2RA使用与全甲状腺切除术后低血症发生率之间的关联.
- 评估过渡性和永久性低血症风险.
- 为了确定甲状腺切除术后低血症的潜在危险因素.
主要方法:
- 使用一个多中心,单一数据库 (TriNetX研究网络) 的回顾性队列研究.
- 分析了34,218名在2011年至2022年期间接受全甲状腺切除术的患者.
- 使用倾向性得分匹配和灵敏度分析,比较患有和没有手术前H2RA处方的患者的低血症发病率.
主要成果:
- 接受H2RA治疗的患者在甲状腺切除术后的0至1个月 (44.9%vs38.3%) 和6至12个月 (11.6%vs8.2%) 显示出显著更高的低血病率.
- H2RA使用者在1个月和6个月后增加了急诊室访问和静脉补充的风险.
- 敏感性分析证实了所有时间点的这些显著关联.
结论:
- 在手术前使用H2RA与甲状腺切除术后短期和长期低血症的风险增加有关.
- 这项研究提供了关于H2RA使用和甲状腺切除术后低血症的首个回顾性队列证据.
- 在接受甲状腺手术的H2RA患者中,临床意识和潜在的药物审查可能是合理的.
相关概念视频
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
Skeleton and Calcium Homeostasis
4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Synthesis and Functions of Calcitonin
1.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
1.6K
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
402
Histamine H2 receptors, which are intricately located on the basolateral membrane of parietal cells, play a crucial role in modulating gastric acid secretion. When released from enterochromaffin-like cells, histamine engages H2 receptors, initiating the cyclic AMP (cAMP) pathway. In this pathway, adenylyl cyclase converts ATP into cAMP, elevating intracellular cAMP levels. The activation of protein kinase A follows, stimulating the proton pump. This stimulation prompts the secretion of hydrogen...
402

