ZNF165:具有预后和治疗潜力的泛癌生物标志物
1Scientific Research Center, Dongguan Labway Medical Testing Laboratory Co., Ltd., Dongguan, 523429, China.
Protein and peptide letters
|January 27, 2025
概括
在许多癌症中,ZNF165基因失调,影响患者的生存和免疫反应. 准ZNF165对新型癌症免疫疗法有很大的前景.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 免疫学 免疫学 免疫学
背景情况:
- 已确定ZNF165在肝,胃和乳腺癌中的作用.
- 它影响瘤免疫微环境,增殖和迁移.
- ZNF165是癌症免疫治疗的潜在目标.
研究的目的:
- 为了研究ZNF165.5.的泛癌景观.
- 了解它对癌症发展和患者结果的影响.
- 探索ZNF165在瘤免疫微环境和药物反应中的作用.
主要方法:
- 使用了在线数据库 (TIMER,TCGA,GTEx,GEPIA2,cBioPortal,TIMER2) 和进行统计分析.
- 评估了ZNF165表达,临床相关性和与MSI,TMB和免疫透的关联.
- 研究了基因变异,信号通路,药物反应和单细胞表达模式.
主要成果:
- 在各种癌症中,ZNF165表达变化,与KIRC,KIRP,STAD和UCEC的临床阶段和低生存率相关.
- 在ZNF165和MSI,TMB,免疫细胞透和免疫检查点基因表达之间发现了显著的关联.
- ZNF165与癌症进展,化疗反应和化学抵抗有关,在卵巢癌中发现了一个ceRNA网络.
结论:
- ZNF165表现出泛癌失调,并与关键的癌症特征有关.
- 它与免疫标记物和临床结果的关联表明它在瘤发生中起着重要作用.
- 在人类癌症治疗中,ZNF165是一个有前途的治疗标.
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