胃癌和癌前病变的危险因素分析:一个病例对照研究
Meng Jie Gao1,2, Song Bo Li1, Xiao Jing Zhu1
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China.
Journal of digestive diseases
|January 27, 2025
概括
胃桑托马 (GX) 与癌前病变 (PCL) 和胃癌 (GC) 有关. PCL和GC的主要风险因素包括年龄,男性性别,农村生活,H. pylori和高血压.
科学领域:
- 胃肠道学和瘤学
- 消化道疾病的流行病学
背景情况:
- 胃瘤 (GX) 是胃镜检查期间的一个值得注意的发现.
- 了解癌前病变 (PCL) 和胃癌 (GC) 的风险因素对于早期检测和预防至关重要.
研究的目的:
- 确定胃桑托马 (GX) 与癌前病变 (PCL) 和胃癌 (GC) 之间的关联.
- 确定中国西北部PCL和GC的其他独立风险因素.
主要方法:
- 一项涉及1250名患者的病例控制研究 (423例慢性胃炎,422例PCL,415例GC),从2022年9月到2023年9月进行.
- 使用单变量和多变量逻辑回归分析来评估风险因素,包括人口统计,生活方式,饮食和Helicobacter pylori (H. pylori) 感染.
主要成果:
- 与慢性胃炎 (CG) 组 (6.15%) 相比,PCL (14.93%) 和GC (19.76%) 组的胃黄瘤 (GX) 患病率显著更高.
- PCL和GC的独立风险因素包括年龄≥50岁,男性性别,农村居住,H. pylori感染,GC,GX和高血压的家族病史.
- 饮食因素,如高盐/香料摄入量和低新鲜水果摄入量,也与GC发生有关.
结论:
- 胃黄瘤 (GX) 是癌前病变 (PCL) 和胃癌 (GC) 的潜在指标.
- 年龄,男性性别,农村居住,H. pylori感染,家族史上的GC,GX和高血压是PCL和GC在这个人群中的重要危险因素.
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