营养刺激激素治疗的试验中的营养和功能结果- 一个系统的映射审查
Sébastien Czernichow1,2,3, Nathalie Rassy1, Claire Carette1,2
1Assistance Publique-Hôpitaux de Paris (AP-HP), Service de Nutrition, Centre Spécialisé Obésité, Hôpital Européen Georges Pompidou, Paris, France.
营养刺激激素疗法 (NuSHs) 对减肥有希望,但研究很少评估身体体重以外的营养和功能结果. 对于这些肥胖治疗方法,需要进行更全面的评估.
科学领域:
- 肥胖研究的研究.
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 营养刺激激素疗法 (NuSHs) 正在研究超重和肥胖个体的减肥.
- 这些试验中对营养和功能结果的评估程度尚不清楚.
研究的目的:
- 系统地绘制随机对照试验 (RCT) 中营养和功能结果的存在,评估体重管理中的NuSHs.
主要方法:
- 在主要的临床试验注册表 (CENTRAL,ClinicalTrials.gov,ICTRP) 进行了系统的映射搜索,用于NuSH的干预试验,直到2023年12月31日.
- 包括的试验符合特定的标准:随机,II/III期,包括体重结果,持续时间≥6个月,并指定BMI值.
- 评估结果包括饮食摄入量,饮食行为,身体组成,身体表现,肌肉强度,骨健康以及特定的生物标志物 (维生素,微量元素,白蛋白,前白蛋白,血红蛋白).
主要成果:
- 在2284个确定的试验中,包括417个. 随着时间的推移,除了体重之外的营养评估报告也越来越多.
- 在20.4%的试验中报告了身体成分,在17.3%的试验中报告了白蛋白/白前蛋白/血红蛋白,在17%的试验中报告了饮食摄入量/饮食行为.
- 骨健康,体力表现,肌肉强度和维生素/微量元素水平均在不到5%的试验中进行了评估.
结论:
- 评估营养刺激激素治疗肥胖的随机对照试验显示,对综合营养和功能结果的报道很少.
- 需要对这些结果进行更彻底的评估,以充分了解超出减肥范围的NuSHs的影响.
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