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Updated: May 30, 2025

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology
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使用暴露-响应分析评估洛帕胺对心脏再极化间隔的影响

Belén Valenzuela1, Per Olsson Gisleskog2, Iolanda Cirillo3

  • 1Janssen-Cilag Spain, Part of Janssen Pharmaceutical Companies of Johnson and Johnson, Madrid, Spain.

Clinical and translational science
|January 27, 2025
PubMed
概括

洛佩拉米德及其代谢物M1在健康成年人中,在治疗剂量或超治疗剂量下,不会显著延长QT间隔. 这项研究没有发现心脏再极化效应超过了对loperamide安全性的监管关注.

关键词:
延长QTc的时间心脏病学心脏病学心脏病学药物开发是药物的发展.建模和模拟的模型和模拟.药物动力学 药物动力学第1阶段第一阶段

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