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Updated: May 30, 2025

High-Throughput Cardiotoxicity Screening Using Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Monolayers
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动态地图照亮了Hippo-cMyc模块的交叉通话,推动了心肌细胞的增殖

Bryana N Harris1, Laura A Woo1, R Noah Perry1

  • 1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908-0759, USA.

Development (Cambridge, England)
|January 27, 2025
PubMed
概括

一个新的计算模型揭示了关键调节者如何协调心肌细胞在心脏发育和再生过程中的增殖. 这项研究确定了一个YAP-cMyc轴,该轴对于驱动细胞循环活动和控制心脏再生至关重要.

关键词:
心肌细胞的增殖和扩散再生再生再生的过程系统生物学 系统生物学

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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