分类SOCS基因及其在巨细胞激活中的作用
1Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
概括
抑制细胞因子信号传递 (SOCS) 蛋白质的抑制剂,如SOCS1,可以交叉调节免疫反应. 由干扰素-诱导的SOCS1抑制了粒细胞巨细胞殖民地刺激因子在巨细胞中的信号传递.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 细胞因子信号传递抑制剂 (SOCS) 基因家族包括八个成员,包括SOCS1-SOCS7和CISH.
- 众所周知,SOCS蛋白可以自我调节细胞因子信号通路.
- 在细胞因子信号传递中SOCS蛋白的交叉调节功能仍然不太了解.
研究的目的:
- 研究SOCS1在细胞因子信号通路上的交叉调节能力.
- 为了确定由一种细胞因子诱导的SOCS1能否影响另一种细胞因子的信号传递.
- 为了阐明SOCS1介导抑制的剂量和时间依赖性.
主要方法:
- 使用来自小鼠骨髓的巨细胞.
- 干扰素- (IFN-γ) 用于诱导SOCS1的表达.
- 分析了花细胞巨细胞殖民地刺激因子 (GM-CSF) 信号传递.
- 进行了SOCS1表达水平和信号抑制的定量评估.
主要成果:
- 由IFN-γ诱导的SOCS1表达被证明可以抑制巨细胞中的GM-CSF信号传递.
- 发现SOCS1对细胞因子信号的抑制作用是剂量依赖的.
- SOCS1表达的临界值水平是必要的,以显著抑制自身隐性 (IFN-γ受体) 和对隐性 (GM-CSF受体) 信号传递.
结论:
- SOCS1在交叉调节细胞因子信号通路方面发挥着重要作用.
- 干扰素-诱导的SOCS1可以调节对其他细胞因子的反应,如GM-CSF.
- 这些发现突出了SOCS蛋白在免疫细胞信号传递和调节中的复杂相互作用.
相关概念视频
01:20The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K
01:01Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
01:25Immune Surveillance by NK Cells and Phagocytes
1.3K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.3K
01:15Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
01:24B Cell Activation and Differentiation
1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K