患者对个性化风险沟通的看法使用多基因风险评分来告知结肠直肠癌查决策
Shauna R Goldberg1, Linda K Ko2,3, Li Hsu2
1Kaiser Permanente Colorado Institute for Health Research, Aurora, Colorado.
AJPM focus
|January 27, 2025
概括
年轻的成年人理解他们个性化的多基因风险评分用于结直肠癌查. 这种方法可能有助于让这一群体参与癌症预防和明智的健康决策.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 50岁以下的个人中结肠直肠癌 (CRC) 发病率正在上升.
- 新的美国指南建议从45岁开始对CRC进行查.
- 多基因风险评分 (PRS) 为CRC提供个性化风险评估.
研究的目的:
- 评估患者对PRS结果的理解.
- 评估PRS在告知CRC选决策中的使用情况.
- 探索患者与个性化遗传风险信息的接触.
主要方法:
- 20名年龄在46-51岁的成年人,提供但尚未进行CRC查,为PRS分析提供唾液.
- 参与者接受了PRS结果后的半结构面试.
- 专题分析被用来解释定性访谈数据.
主要成果:
- 19名参与者完成了PRS测试和采访.
- 一位参与者对CRC的PRS很高.
- 采访显示了参与者的理解,对PRS的信任,风险感知和查意图.
结论:
- 参与者对他们的PRS结果表现出理解和兴趣.
- 需要进一步的研究来制定PRS实施的指导方针和教育材料.
- 提供者参与策略对于将PRS纳入临床实践至关重要.
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