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Updated: May 30, 2025

Efficient Mammalian Cell Expression and Single-step Purification of Extracellular Glycoproteins for Crystallization
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TREM2的细胞外域具有两个不同的连接体识别点:来自机器学习引导对接和全原子分子动力学模拟的洞察力

Sarbani Mishra1, Preety Sthutika Swain1, Sanghamitra Pati1

  • 1ICMR-regional Medical Research Centre, Nalco Square, Chandrasekharpur, Bhubaneswar, 751023, Odisha, India.

Heliyon
|January 27, 2025
PubMed
概括

研究人员确定了第二个TREM2连接体结合部位,这对于了解阿尔茨海默病 (AD) 和开发新疗法至关重要. 这一发现揭示了TREM2变异如何影响AD进展.

关键词:
AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD AD ADD was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was was确定互补性的地区.突变突变是一种突变.在 NHD 的情况下,它是 NHD.神经退行性疾病 神经退行性疾病在Trem2 ECD中使用.

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