相关实验视频
Updated: Jul 10, 2026

11:11
Isolation of Sertoli Cells and Peritubular Cells from Rat Testes
Published on: February 8, 2016
22.4K
维门丁作为SARS-CoV-2诱导的耳炎的促成因素在COVID-19病例的死后丸解剖中:一项病例控制研究
Soheila Akaberi-Nasrabadi1, Azam Sabbaghi1, Behzad M Toosi2
1Urology and Nephrology Research Center, Research Institute for Urology and Nephrology, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.
International journal of reproductive biomedicine
|January 27, 2025
概括
维门的表达与COVID-19患者的丸损伤有关. 这表明维门丁可能作为SARS-CoV-2诱导的丸损伤和影响精子生成的生物标志物.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 流行病是由SARS-CoV-2引起的.
- SARS-CoV-2利用宿主细胞受体和共受体进入.
- 在丸组织中高度表达的维门丁是潜在的SARS-CoV-2共受体.
研究的目的:
- 调查维门丁表达与SARS-CoV-2诱导的耳炎之间的关联.
- 为了评估维门丁在COVID-19感染后的丸病理中的作用.
主要方法:
- 从COVID-19病例和对照中使用尸检丸样本进行病例对照研究设计.
- 进行了基因表达和免疫组织化学分析.
- 评估了维丁表达,免疫细胞透和增殖标志物.
主要成果:
- 在COVID-19病例中显著的维门丁表达和免疫细胞透 (CD68+,CD38+,CD138+).
- 观察到免疫球蛋白G沉增加和抑制素表达减少.
- 增加的维丁和减少的增殖标志物 (Ki67,PCNA) 表明精子生成受损.
结论:
- 维门丁表达与COVID-19引起的耳炎之间存在着强烈的联系.
- 维丁可能作为COVID-19中丸损伤的生物标志物.
- 通过免疫反应和细胞增殖停止,SARS-CoV-2可能会损害精子生成.
相关概念视频
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Testes: Histology
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The spermatogenic cells, responsible for producing sperm, are...
Infertility in Males
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
Viral Meningitis
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...

