索拉费尼布作为肝移植后辅助疗法:单中心体验
Hala Hassanain1, Ashton A Connor1, Elizabeth W Brombosz1
1Department of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Transplantation direct
|January 27, 2025
概括
肝细胞癌肝移植后的辅助索拉费尼布治疗没有改善整体存活率. 虽然与无复发生存率的改善无关,但它与高风险患者的不良事件有关.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 在北美,肝细胞癌 (HCC) 的发病率和死亡率正在增加.
- 肝移植 (LT) 是对HCC的有效治疗方法,但复发仍然是一个重大问题.
- 研究辅助全身疗法以减少LT后的HCC复发至关重要.
研究的目的:
- 评估辅助性索拉费尼布在减少复发和改善HCCLT后的存活率方面的疗效.
- 为了比较接受辅助索拉费尼布的患者,高风险的非接受者和低风险的非接受者之间的结果.
主要方法:
- 在2016年至2022年期间,对273名为HCC接受LT的患者进行了回顾性审查.
- 分为辅助性索拉费尼布接受者,高风险非接受者和低风险非接受者.
- 总生存率 (OS) 和无复发生存率 (RFS) 的分析,与倾向性得分匹配.
主要成果:
- 16名患者 (5.9%) 接受了辅助索拉费尼布;这些患者的瘤负担较高,预后特征较差.
- 辅助性索拉费尼布与改善的生存状况无关 (P=0.62) 并与显著缩短的RFS (P=0.001) 有关.
- 75%的索拉费尼布接受者出现了不良事件;倾向匹配没有显示与OS或RFS相关.
结论:
- 在这个队列中,辅助索拉费尼布治疗与改善的整体存活率不相关.
- 索拉费尼布接受者的较短RFS可能归因于他们患有高风险特征的患病率较高.
- 较高的不良事件率和缺乏生存益处表明,辅助性索拉费尼布在这种情况下的效用有限.
相关概念视频
Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...


