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Updated: May 30, 2025

Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture
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Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture

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链交换的SH3域调光剂具有超氧化物脱酶活性

Florian R Häge1, Merlin Schwan2, Marcos Rafael Conde González1,3

  • 1Institute of Organic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.

ACS central science
|January 27, 2025
PubMed
概括

研究人员设计了一种小型的超氧化物脱酶 (SOD) 模型,SO1,通过将一个铜结合部位纳入一个小蛋白质. 这种新型金属蛋白具有显著的SOD活性,为设计双核金属蛋白提供了一个新的模板.

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Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans12:57

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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