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Updated: May 30, 2025

Residue-specific Incorporation of Noncanonical Amino Acids into Model Proteins Using an Escherichia coli Cell-free Transcription-translation System
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计算辅助的非正规氨基酸整合

Chengzhu Fang1,2, Wenyuan Xu1,2, Chao Liu1,2

  • 1The Second Affiliated Hospital of Zhejiang University School of Medicine, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

ACS central science
|January 27, 2025
PubMed
概括

我们开发了一个虚拟选器,快速识别和将新型非正规氨基酸 (ncAAs) 纳入蛋白质中. 该工具加速了用于生物研究和药物开发的功能性蛋白质的设计.

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From DNA to Protein03:06

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The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
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