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多发性硬化症患者的疫苗接种覆盖率及其决定因素 - 一项多中心横截面研究

Paula Schade¹, Hai-Anh Nguyen¹, Julia Steinle²

¹Department of Neurology, Jena University Hospital, Jena, Germany.

Therapeutic advances in neurological disorders

|January 27, 2025

概括

多发性硬化症 (pwMS) 患者的疫苗接种覆盖率很低,即使是那些接受疾病修饰疗法 (DMT) 患者. 一般医生 (GPs) 对疫苗安全性和DMT相互作用的担忧可能导致 pwMS 中的疫苗接种率较低.

科学领域:

神经学神经学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

多发性硬化症 (MS) 协会建议对多发性硬化症 (pwMS) 患者进行完整的疫苗接种,以预防感染,特别是在使用疾病修饰疗法 (DMT) 时.
了解疫苗接种覆盖率及其影响pwMS的因素对于管理感染风险至关重要.
本研究研究了pwMS患者的疫苗接种率与健康个体相比,考虑了心理和职业因素.

研究的目的:

分析pwMS中的疫苗接种覆盖率与健康对照.
确定疫苗接种覆盖率的决定因素,包括犹,MS特定的信念,对信息来源的信任以及全科医生的作用.
评估DMT对pwMS疫苗接种率的影响.

主要方法:

在德国6个多发性硬化中心进行了横截面,多中心的观察研究.
疫苗接种覆盖率使用基于八次标准疫苗接种的疫苗接种指数 (VI) 进行评估.
数据通过问卷,疫苗卡分析和全科医生调查收集.

主要成果:

疫苗接种指数 (VI) 在pwMS (n=397) 中略低于健康对照组 (n=300;p=0.057).
疫苗接种犹是低的,在各组之间是相似的;它解释了只有10%-16%的VI变异.
82%的全科医生表示不愿接种pwMS疫苗,因为担心MS的副作用或DMT的相互作用.

结论:

在pwMS中接种疫苗覆盖率令人担忧地低,即使对于那些使用高效的DMT的人来说也是如此,并且往往低于健康对照群.
诸如疫苗接种犹之类的内在因素并不能完全解释这种低病率.
由于安全性和DMT相互作用的担忧,全科医生的不一致的疫苗接种建议可能会大大导致 pwMS 中的疫苗接种覆盖率不足.

关键词:

疾病改变治疗方法.感染的风险感染的风险.多发性硬化症多发性硬化症接种疫苗接种疫苗疫苗接种犹犹疫苗接种犹

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