感染SARS-CoV-2是否会增加神经精神病和相关疾病的风险? 差异差异分析的发现
Yong Chen1, Yiwen Lu1, Jiayi Tong2
1University of Pennsylvania.
Research square
|January 27, 2025
概括
在儿童和青少年中,COVID-19感染增加了神经精神疾病的风险. SARS-CoV-2 (导致COVID-19的病毒) 与诸如焦虑,多动症和抑郁症等疾病有关,超出了流行病压力.
科学领域:
- 儿童神经精神病学
- 传染病流行病学 传染病流行病学
- 公共卫生 公共卫生
背景情况:
- 由于COVID-19的流行,年轻人中神经精神病的发病率有所上升.
- 新出现的证据表明,SARS-CoV-2感染本身可能会增加超出一般流行病相关压力因素的风险.
研究的目的:
- 评估SARS-CoV-2阳性儿童和青少年的神经精神疾病的范围.
- 将这些结果与匹配的SARS-CoV-2阴性个体队列进行比较.
- 确定不同年龄组感染的特定风险.
主要方法:
- 从RECOVER计划 (25个机构) 获得的电子健康记录的回顾性分析.
- 包括326,074名COVID-19阳性和887,314名COVID-19阴性参与者,根据风险因素匹配并按年龄分层.
- 神经精神病学结果的评估 感染后28179天/阴性测试 (2020年3月至2022年12月).
- 通过PCR,血清学或抗原检测确认SARS-CoV-2状态.
主要成果:
- COVID-19阳性儿童 (5-12) 显示焦虑,强迫症,多动症和自闭症的风险增加.
- 在COVID-19阳性青年 (12-20岁) 中,焦虑,自杀倾向,抑郁和相关症状的风险较高.
- 与负面队列相比,SARS-CoV-2阳性队列中神经精神疾病的发生频率更高.
结论:
- 感染SARS-CoV-2与儿童和青少年神经精神疾病的发病率较高有关.
- 这些发现强调需要进一步研究将感染与神经精神病结局联系在一起的机制.
- 强调开发针对性治疗和预防策略对受影响人群的重要性.
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