自身免疫性脑炎的多样化临床特征和结果:回顾一系列病例
Aruna Kumari Kotteti1, Elanthiraiyan Govindaswamy Chelvakumar1, Robert Wilson Sundaram1
1Neurology, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND.
Cureus
|January 27, 2025
概括
早期诊断自身免疫性脑炎 (AE) 对于有效治疗至关重要. 及时的免疫抑制疗法显著改善了结果,即使是在具有负抗体面板的非典型病例中.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 自身免疫性脑炎 (AE) 呈现出各种不同的临床表现.
- 了解临床概况,调查和预后对于患者管理至关重要.
研究的目的:
- 在七个AE病例中分析临床特征,诊断结果,治疗结果和预后因素.
- 突出早期诊断和AE及时治疗的重要性.
主要方法:
- 七名AE患者的临床记录的回顾性分析.
- 数据采集于2022年7月至2023年12月期间,在奈的SRM医学院医院和研究中心收集.
主要成果:
- 所有七名患者 (年龄在18-35岁) 都出现了发作;只有两个有认知/精神问题.
- 三个病例检测出抗N-甲基-D-酸盐受体 (抗NMDAR) 抗体呈阳性;其他病例的AE面板呈阴性.
- 在所有患者中,脑部MRI与对比是正常的.
结论:
- 早期诊断AE对于通过及时的免疫抑制治疗来降低发病率和死亡率至关重要.
- 详细的病史,临床检查和调查是诊断的关键.
- 越来越多地观察到轻度的非典型AE,具有负抗体面板和良好的结果.
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