MAFLD:探索肝脏以外的系统性影响
Utkarsh Dayal1, Ujjwal Soni2, Sourav Bansal3
1Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA.
Journal of community hospital internal medicine perspectives
|January 27, 2025
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与慢性病和心血管疾病的风险增加有关. 了解肠-肝-轴是管理这些相互关联的健康问题的关键.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一种由肥胖和糖尿病驱动的普遍疾病.
- MAFLD涵盖了一系列的肝脏脂肪积累,从简单的肥胖症到晚期肝脏疾病.
- MAFLD与重大并发症有关,包括慢性病 (CKD) 和心血管疾病 (CVD).
研究的目的:
- 审查MAFLD,心血管并发症和脏问题之间的复杂联系.
- 突出肠-肝-轴在MAFLD病变发生过程中的作用.
- 强调了解病理生理路径对于管理MAFLD相关风险的重要性.
主要方法:
- 对当前科学文献进行前性审查.
- 对代谢功能障碍,肝病,肠道微生物组和全身并发症之间的相互作用研究的分析.
- 综合证据,将炎症,氧化应激和胰岛素抵抗与MAFLD并发症联系起来.
主要成果:
- MAFLD的发病包括炎症,氧化应激,胰岛素抵抗和内皮功能障碍,有助于心血管疾病风险.
- 肠道功能障碍越来越被认为是MAFLD的一个因素,特别是与CKD的关联.
- 肝硬化和代谢功能障碍是MAFLD诊断及其与其他肝脏疾病的同时发生的核心因素.
结论:
- MAFLD显著增加了CKD,CVD和其他肝脏并发症的风险.
- 肠-肝-轴在MAFLD及其相关疾病的发展和进展中发挥着关键作用.
- 对这些相互关联的途径进行进一步的研究对于有效的临床管理和预防策略至关重要.
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