在患有结核病和没有结核病的幼儿中对Mycobacterium tuberculosis的免疫敏感化
medRxiv : the preprint server for health sciences
|January 27, 2025
概括
结核素皮肤测试 (TST) 发现了比QuantiFERON Gold Plus (QFT-Plus) 更多的对Mycobacterium结核病 (Mtb) 敏感的儿童. 推TST用于评估暴露于结核病的幼儿的Mtb敏感性.
科学领域:
- 儿童传染病 儿童传染病
- 菌根菌感染 菌根菌感染
- 诊断免疫学的诊断免疫学
背景情况:
- 在幼儿中早期发现Mycobacterium结核病 (Mtb) 感染对于降低结核病 (TB) 发病率和死亡率至关重要.
- 在这个年龄组中,对Mtb感染的最佳诊断测试仍在争论中.
研究的目的:
- 为了比较结核素皮肤测试 (TST) 和QuantiFERON Gold Plus (QFT-Plus) 在识别幼儿mtb敏感性的有效性.
- 评估诊断测试结果与活跃结核病疾病的几率之间的关联.
主要方法:
- 结核病家庭接触 (HHC) 研究设计用于130名乌干达5岁以下的儿童,这些儿童暴露于Mtb.
- 在检测mtb敏感性方面,TST和QFT-Plus进行了比较.
- 进行了单变量分析和逻辑回归来评估结核病风险.
主要成果:
- 5毫米的TST值发现了更多的Mtb敏感儿童,特别是那些患有活跃结核病的儿童.
- 阳性TST的儿童患有活跃结核病的几率大约是两倍 (aOR:2.09).
- 在QFT-Plus TB管1和TB管2的结果显示出很高的一致性.
结论:
- 在暴露于结核病的幼儿中,TST在识别Mtb敏感性方面比QFT-Plus更有效.
- 这些发现对结核病在流行地区的高性结核病患者具有重要意义.
- 建议继续使用TST来评估幼儿的Mtb敏感性.
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